Anxiolytic drugs: dependence, addiction and abuse

@article{Lader1994AnxiolyticDD,
  title={Anxiolytic drugs: dependence, addiction and abuse},
  author={Malcolm Harold Lader},
  journal={European Neuropsychopharmacology},
  year={1994},
  volume={4},
  pages={85-91}
}
  • M. Lader
  • Published 1 June 1994
  • Psychology, Medicine
  • European Neuropsychopharmacology
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References

SHOWING 1-10 OF 30 REFERENCES
A pilot study of the effects of flumazenil on symptoms persisting after benzodiazepine withdrawal
TLDR
The benefits last between a few hours and several days despite flumazenil's otherwise short duration of action, however, symptoms did return to varying degrees in most cases, suggesting the need for repeated doses.
Patterns of benzodiazepine abuse and dependence.
TLDR
Two groups of subjects emerged: patients who used only benzodiazepines for long periods of time and those who used Benzodiazepine in the context of multiple drug abuse, where Diazepam was most frequently alleged in both groups, but relative preference for other benzodiazines differed.
The prolonged benzodiazepine withdrawal syndrome: anxiety or hysteria?
TLDR
It was concluded that PWS is likely to be a genuine iatrogenic condition, a complication of long‐term benzodiazepine treatment.
Benzodiazepine withdrawal phenomena.
TLDR
The withdrawal syndrome subsided after 2 weeks and was similar in both groups of patients and EEG changes were detected on withdrawal opposite to those known to be associated with initiation of diazepam treatment.
Biological processes in benzodiazepine dependence.
  • M. Lader
  • Psychology, Biology
    Addiction
  • 1994
TLDR
The molecular pharmacology of the benzodiazepine-GABA-chloride receptor is complex, with a wide range of different subunits and various clinical implications are explored, including the use of flumazenil to prevent and to treat Benzodiazepines withdrawal syndromes.
Comparison of diazepam and oxazepam: preference, liking and extent of abuse.
TLDR
Previous experimental observations suggesting that diazepam has a higher abuse liability than oxazepam are extended, compatible with an analysis of epidemiological data showing thatdiazepam abuse uniformly exceeds oxzepam abuse on seven epidemiological measures of drug abuse.
Long-term treatment of anxiety and risk of withdrawal. Prospective comparison of clorazepate and buspirone.
TLDR
There was a significant increase in symptom severity consistent with a withdrawal reaction for the clorazepate group but not the buspirone group, and there was a suggestion that previous discontinuous exposure to benzodiazepines might sensitize patients to subsequent withdrawal effects.
The practical business of treatment. XVII, Benzodiazepine problems
TLDR
Patients with apparent benzodiazepine dependence need careful assessment with respect to personality, social situation and psychiatric disorder and must be motivated and carefully prepared for withdrawal and taught anxiety management techniques.
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