Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice.

@article{Yao2010AnxiolyticAS,
  title={Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice.},
  author={Y C Yao and Min Jia and Jianguo Wu and Hong Zhang and Lian-na Sun and Wansheng Chen and Khalid Rahman},
  journal={Pharmaceutical biology},
  year={2010},
  volume={48 7},
  pages={801-7}
}
In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, and sodium pentobarbital-induced hypnosis tests. Moreover, the acute toxicity of polygalasaponins was also estimated in mice. Sixty minutes after p.o. administration of polygalasaponins (40, 80, 160 mg/kg) in mice, the central crossing counts and percentage of central/total… CONTINUE READING