Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.

@article{Swanson2005AnxiolyticAA,
  title={Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.},
  author={Chad J. Swanson and Thomas Blackburn and Xuexiang Zhang and Kang Zheng and Z. Q. D. Xu and Tomas G M H{\"o}kfelt and Toni D Wolinsky and Michael J Konkel and Heidi Chen and Huailing Zhong and Mary W. Walker and Douglas A. Craig and Christophe P G Gerald and Theresa A. Branchek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 48},
  pages={17489-94}
}
The neuropeptide galanin mediates its effects through the receptor subtypes Gal(1), Gal(2), and Gal(3) and has been implicated in anxiety- and depression-related behaviors. Nevertheless, the receptor subtypes relevant to these behaviors are not known because of the lack of available galanin-selective ligands. In this article, we use behavioral, neurochemical, and electrophysiological approaches to investigate the anxiolytic- and antidepressant-like effects of two potent small-molecule, Gal(3… CONTINUE READING