Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.

  title={Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.},
  author={James Oluwagbamigbe Fajemiroye and Pablinny Moreira Galdino and Joelma Abadia Marciano de Paula and Fagundes Fabio Rocha and Moses Atanda Akanmu and Frederico Argollo Vanderlinde and Jordan Kordian Zjawiony and Elson A Costa},
  journal={Food & function},
  volume={5 8},
(E)-methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for treating mood disorders appears to be globally attractive. Hence, we sought to evaluate general pharmacological activities, anticonvulsant, anxiolytic and antidepressant effects and the possible mechanisms of MIE actions. Administration of MIE… CONTINUE READING
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