Anxiolytic activity of steroid anesthetic alphaxalone.

  title={Anxiolytic activity of steroid anesthetic alphaxalone.},
  author={Karen Thatcher Britton and Martin Pag{\'e} and Hilary Baldwin and George F. Koob},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={258 1},
The synthetic steroid anesthetic alphaxalone (3 alpha-hydroxy-5 alpha-pregnane-11,20-dione) was studied in two behavioral paradigms known to be sensitive to anxiolytic drugs. In an elevated plus maze, alphaxalone produced an anxiolytic profile, significantly increasing the percentage of entries made into the open arms as well as the percentage of time spent on the open arms. In the conflict test, alphaxalone (6 and 8 mg/kg) produced a significant dose-dependent increase in punished responding… CONTINUE READING
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