Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone.

@article{Harada2006AnxiolyticAO,
  title={Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone.},
  author={Katsuya Harada and Masaki Aota and Tatsuo Inoue and Ritsuko Matsuda and Takuma Mihara and Takayuki Yamaji and Koji Ishibashi and Nobuya Matsuoka},
  journal={European journal of pharmacology},
  year={2006},
  volume={553 1-3},
  pages={171-84}
}
Hyperfunction of brain 5-hydroxytryptamine(2C) (5-HT(2C)) receptor is suggested to be involved in anxiety as evidenced by the fact that a putative 5-HT(2C) receptor agonist 1-(m-chlorophenyl)-piperazine (m-CPP) causes anxiety in humans. We have recently identified FR260010 (N-[3-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6-dihydrobenzo[h]quinazolin-4-amine dimethanesulfonate) as novel 5-HT(2C) receptor antagonist from diaryl amine derivatives, and here characterized in vitro and in vivo profiles of… CONTINUE READING