Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test.

@article{File1997AnxiolyticAO,
  title={Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test.},
  author={S. E. File},
  journal={Pharmacology, biochemistry, and behavior},
  year={1997},
  volume={58 3},
  pages={747-52}
}
  • S. E. File
  • Published 1997 in Pharmacology, biochemistry, and behavior
CGP 49823, a substance P antagonist acting at NK1 receptors, had significant anxiolytic effects at 3, 10 and 30 mg/kg orally in the high-light unfamiliar and low-light unfamiliar conditions of the social interaction test but was without effect in the low-light familiar condition. The effects were less marked after 3 and 6 weeks of treatment (10 mg/kg/day), indicating that some tolerance had developed, but a significant anxiolytic effect still remained. After 3 weeks of diazepam treatment (2 mg… CONTINUE READING

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