Anxiolytic Properties of the Selective, Non-peptidergic CRF1 Antagonists, CP154,526 and DMP695: A Comparison to Other Classes of Anxiolytic Agent

@article{Millan2001AnxiolyticPO,
  title={Anxiolytic Properties of the Selective, Non-peptidergic CRF1 Antagonists, CP154,526 and DMP695: A Comparison to Other Classes of Anxiolytic Agent},
  author={Mark John Millan and Mauricette Brocco and Alain P Gobert and Gilbert Dorey and Patrick Casara and Anne Dekeyne},
  journal={Neuropsychopharmacology},
  year={2001},
  volume={25},
  pages={585-600}
}
The selective, non-peptidergic corticotropin-releasing factor (CRF)1 receptor antagonists, CP154,526 and DMP695, dose-dependently increased punished responses of rats in a Vogel conflict test and enhanced social interaction (SI) of rats in an unfamiliar environment. They were, however, inactive in a plus-maze procedure and failed to reduce ultrasonic vocalizations (USV) associated with an aversive environment. In contrast, the benzodiazepine, chlordiazepoxide, was effective in all these… CONTINUE READING

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