Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder

@article{Zhang2012AnxiolyticEO,
  title={Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder},
  author={Li-ming Zhang and Jiarong Yao and Yang Li and Kai Li and Hong-xia Chen and You-zhi Zhang and Yun Feng Li},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  year={2012},
  volume={2012}
}
  • Li-ming Zhang, Jiarong Yao, Y. Li
  • Published 13 December 2012
  • Biology, Psychology
  • Evidence-based Complementary and Alternative Medicine : eCAM
The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction… 

Figures and Tables from this paper

Anti-PTSD-like effects of albiflorin extracted from Radix paeoniae Alba.
The anxiolytic-like effects of estazolam on a PTSD animal model
The anxiolytic-like effects of puerarin on an animal model of PTSD.
Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder
TLDR
The anti-PTSD-like activities of PF were associated with the modulation of HPA axis and 5-HT system activation.
Comparison between cannabidiol and sertraline for the modulation of post-traumatic stress disorder-like behaviors and fear memory in mice
TLDR
Cannabidiol produced anti-PTSD-like actions in mice and disrupted trauma-related fear memory by interfering with multiple aspects of fear memory processing, indicating that CBD may be a promising candidate for treating PTSD.
Anxiolytic effects of GLYX-13 in animal models of posttraumatic stress disorder-like behavior
TLDR
The results suggest that GLYX-13 exerts a therapeutic effect on PTSD-like stress responding that is accompanied by (or associated with) modulation of the HPA axis, including inhibition of stress hormone levels and upregulation of hippocampal GR expression.
Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis
TLDR
It is demonstrated that midazolam improves the behavioral deficits in the SPS model through dual TSPO and CBR and neurosteroidogenesis.
The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain
TLDR
It is indicated that puerarin exerted the anxiolytic-like effects, which maybe associated with normalization of 5-HT levels and biosynthesis of allopregnanolone in brain.
Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic-Pituitary-Adrenal Axis Dysfunction, and Alternations in Hippocampal BDNF Expression Under Single Prolonged Stress.
TLDR
EGCG reversed learning and memory-related behavioral dysfunction and molecular alternation accelerated by traumatic stress and may be a useful therapeutic material for PTSD.
...
...

References

SHOWING 1-10 OF 51 REFERENCES
Single prolonged stress: toward an animal model of posttraumatic stress disorder
TLDR
The enhanced consolidation and impaired extinction of fear memory found in SPS rats suggests that this model has additional value because recent studies of PTSD indicate that memory abnormalities are a central feature.
The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder
Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang
Total Flavonoids Extracted from Xiaobuxin-Tang on the Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis in Chronically Stressed Rats
TLDR
The modulation of HPA axis produced by XBXT-2, including the inhibition of stress hormones levels and up-regulation of hippocampal GRs expression, may be an important mechanism underlying its antidepressant-like effect in chronically stressed rats.
Selective serotonin reuptake inhibitors in post-traumatic stress disorder
TLDR
There is increasing evidence to support the use of antidepressants, and particularly selective serotonin reuptake inhibitors (SSRIs), as first-line therapy, and some SSRIs are also effective for the treatment of common comorbidities, such as depression, panic disorder and social anxiety disorder.
Platelet serotonergic markers in posttraumatic stress disorder
The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats
...
...