Anxiolytic Activity of Intraventricularly Administered Atrial Natriuretic Peptide in the Rat

@article{Bhattacharya1996AnxiolyticAO,
  title={Anxiolytic Activity of Intraventricularly Administered Atrial Natriuretic Peptide in the Rat},
  author={Salil Kumar Bhattacharya and Amit Chakrabarti and Merton Sandler and Vivette Glover},
  journal={Neuropsychopharmacology},
  year={1996},
  volume={15},
  pages={199-206}
}
Rat atrial natriuretic peptide (ANP) was investigated for putative anxiolytic activity in rats, following intracerebroventricular (ICV) administration. ANP in doses of 200 and 500 ng/rat induced significant anxiolysis, comparable with that of lorazepam (0.5 mg/kg, IP) in a variety of anxiety models (open-field, elevated plus-maze, social interaction, and novelty-induced feeding suppression tests). Isatin, an endogenous anxiogenic indole, shown to be an antagonist of ANP in vitro, significantly… CONTINUE READING

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