Anxiogenic-like effects of chronic cannabidiol administration in rats

@article{Elbatsh2011AnxiogeniclikeEO,
  title={Anxiogenic-like effects of chronic cannabidiol administration in rats},
  author={M. Elbatsh and N. Assareh and C. Marsden and D. Kendall},
  journal={Psychopharmacology},
  year={2011},
  volume={221},
  pages={239-247}
}
RationalSeveral pre-clinical and human-based studies have shown that acutely administered cannabidiol (CBD) can produce anxiolytic-like effectsObjectivesThe present study investigated the effects of chronic administration of CBD on rat behaviour and on the expression of brain proteins.MethodsMale Lister-hooded rats (150–200 g, n = 8 per group) received daily injections of CBD (10 mg/kg, i.p.) for 14 days. The rats were subjected to two behavioural tests: locomotor activity and conditioned… Expand
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