Anxiogenic-like effect of serotonin1B receptor stimulation in the rat elevated plus-maze

  title={Anxiogenic-like effect of serotonin1B receptor stimulation in the rat elevated plus-maze},
  author={Daniel Lin and Loren H. Parsons},
  journal={Pharmacology Biochemistry and Behavior},
  • D. LinL. Parsons
  • Published 1 April 2002
  • Psychology, Biology
  • Pharmacology Biochemistry and Behavior

A and 5 HT 1 B receptors of medial prefrontal cortex modulate anxiogenic-like ehaviors in rats

The role of 5HT1A and5HT1B receptors of the MPFC in modulation of anxiety behaviors in rats was evaluated to evaluate the effects of anxiogenic or anxiolytic drugs in rodents.

Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression

The results indicate that the selective agonist (CP 94253) and antagonists (SB 216641 and GR 127935) of 5-HT1B receptors produce effects that are characteristic of anxiolytics, in the preclinical models used; however, CP 94253 also behaves like an antidepressant drug.

Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents

  • Y. Sari
  • Medicine, Biology
    Journal of psychopharmacology
  • 2013
This review on the role of 5-HT1B receptors in neurotransmitter release and consequent alcohol intake provides important information about the potential therapeutic role of 4-HT2A receptors for the treatment of alcohol dependence.

Stress-Induced Hyperthermia, the Serotonin System and Anxiety

The present review aims to discuss the acute and chronic effects of 5-HT ligands on the SIH response, and theSIH response in genetically modified mice that lack or overexpress specific serotonergic receptor subtypes or the serotonin transporter will be summarized.

Neonatal DSP-4 treatment impairs 5-HT(1B) receptor reactivity in adult rats. Behavioral and biochemical studies.




Comparative Study of Pre- and Postsynaptic 5-HT1AReceptor Modulation of Anxiety in Two Ethological Animal Tests

Evidence is provided that stimulation of the presynaptic 5-HT1A receptors in the median raphénucleus results in an anxiolytic action, whereas stimulation of those of the post-synaptic 4- HT1Areceptors in its projection area of the dorsal hippocampus results in a anxiogenic effect.

Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors

Three 5-HT agonists produced a dose-related fall in open/total arm entry ratio in the elevated X-maze model of anxiety at doses which did not affect total entries, which may indicate involvement of 5- HT receptors in anxiety separately from any change in the ability to withhold a response.

Endogenous acetylcholine in the dorsal hippocampus reduces anxiety through actions on nicotinic and muscarinic1 receptors.

Dorsal hippocampal cholinergic modulation of behavior in different tests of anxiety was investigated by direct injection of the muscarinic M1 and M2 receptor antagonists, pirenzepine and gallamine, and the nicotinic receptor antagonist mecamylamine, finding that M2 receptors in this brain region do not play a significant role in this behavioral test.

The effects of administration of mCPP on psychological, cognitive, cardiovascular, hormonal and MHPG measurements in human volunteers

The results confirm previous findings that in humans mCPP causes significant increases in the symptoms of anxiety, and in the plasma concentrations of cortisol, prolactin and growth hormone, and demonstrate that m CPP causes no significant changes in cognitive performance, in pulse or systolic blood pressure, or the plasma concentration of MHPG.

Central Serotonin and Impulsive Aggression

  • E. Coccaro
  • Psychology, Biology
    British Journal of Psychiatry
  • 1989
Preliminary data with the 5- HT receptor agonist m-chlorophenylpiperazine suggest that reduced activity of post-synaptic 5-HT receptors may be an important correlate of impulsive aggressive behaviour in psychiatric patients.

Serotonergic functions in arousal and motor activity

  • M. Geyer
  • Biology, Psychology
    Behavioural Brain Research
  • 1995