Anxiogenic effects of Sumatriptan in panic disorder: A double-blind, placebo-controlled study

  title={Anxiogenic effects of Sumatriptan in panic disorder: A double-blind, placebo-controlled study},
  author={Daniella Amital and Leah Fostick and Yehuda Sasson and Seth Kindler and Howard Amital and Joseph Zohar},
  journal={European Neuropsychopharmacology},

New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine

This systematic review aims to systematically review the evidence currently available on the efficacy, safety and tolerability of VRX in the treatment of GAD and reports a significant improvement in anxiety symptomatology compared to three with negative findings.

Protective Effects of Lithium on Sumatriptan-Induced Memory Impairment in Mice.

It is concluded that lithium reverses the sumatriptan-induced memory impairment probably through 5-HT1B/1D receptors antagonism.

Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway

This study provides the first evidence for involvement of TLR4 signaling through MyD88 in initiating and maintaining migraine-like behavior and nucleus caudalis neuronal activation in the mouse.

Serotonin: from top to bottom

It is demonstrated that serotonin is potentially involved in whole organism aging through its links with multiple organs, the immune system and microRNAs and methods to investigate these links are discussed.

A Mini Review of Serotonin and Its Receptors

Major focus of paper is to review subtypes of serotonin receptors and up-to-date information about other pharmacologic agents such as agonist and antagonist of serotonin.



Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin

The findings of the present study do not support the hypothesis that 5-HT2 receptors are supersensitive in patients suffering from panic disorder, but allow no conclusions about the involvement of other 5- HT receptor subtypes.

Sumatriptan (5-HT1D receptor agonist) does not exacerbate symptoms in obsessive compulsive disorder

No indication were found for the role of the 5-HTID receptor in the pathophysiology of OCD, and it should be noted, however, that sumatriptan does not readily pass the blood-brain barrier.

A comparative examination of a role for serotonin in obsessive compulsive disorder, panic disorder, and anxiety.

Patients with OCD were markedly more responsive to treatment with 5-HT-selective uptake inhibitors such as clomipramine, fluvoxamine, or fluoxetine than to norepinephrine- selective or nonselectiveTake inhibitors or to other psychoactive drugs.

Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder

A significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP and this data support the hypothesis of 5HT receptor hypersensitivity in PD.

Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls.

Following mCPP, but not following placebo, patients with OCD experienced a transient but marked exacerbation of obsessive-compulsive symptoms, consistent with a special role for the neurotransmitter serotonin in OCD psychopathology.

Obsessive‐Compulsive Disorder: Treatment with Serotonin‐Selective Uptake Inhibitors, Azapirones, and Other Agents

Investigations that used other drugs with serotonergic actions either alone or in combination with selective 5‐HT uptake inhibitors in OCD patients found these drugs to be more effective than placebo.

Serotonin and anxiety revisited

Dopaminergic and serotonergic effects of clozapine. Implications for a unique clinical profile.

It is proposed that the selective interaction of clozapine among D2, D1, D4 and 5-HT2 receptors results in a distinctive alteration in the function of pre- and post-synaptic dopamine elements.