Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat.

@article{Blokland2002AnxiogenicAD,
  title={Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat.},
  author={Arjan Blokland and Cindy K. J. Lieben and Nicolaas E P Deutz},
  journal={Journal of psychopharmacology},
  year={2002},
  volume={16 1},
  pages={39-49}
}
The tryptophan (TRP) depletion method has been used as a tool to investigate the effects of acute lowered serotonin levels in the brain. In the present study, the effects of this treatment were investigated in rat models of anxiety (open field test, home cage emergence test), depression (forced swimming test, sucrose preference test) and cognition (spatial discrimination learning, sustained attention). It was found that the repeated TRP depletion increased anxiety-related behaviour in the open… CONTINUE READING