Anxiogenic activity of Myristica fragrans seeds.

  title={Anxiogenic activity of Myristica fragrans seeds.},
  author={Ganeshchandra S Sonavane and Vikram Sarveiya and Veena S. Kasture and Sanjay B. Kasture},
  journal={Pharmacology, biochemistry, and behavior},
  volume={71 1-2},
In the present study, the n-hexane extract of Myristica fragrans (MF) seeds, acetone-insoluble part of the n-hexane extract (AIMF) and trimyristin (TM) were assessed for their anxiogenic activity. The MF (10 and 30 mg/kg), AIMF (30, 100, and 300 mg/kg), and TM (10, 30, and 100 mg/kg) administered intraperitoneally exhibited anxiogenic activity in elevated plus-maze (EPM) paradigm. The open-field test and hole-board test were also used to assess anxiogenic activity of AIMF and TM. In the EPM… CONTINUE READING

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