Anxiogenic action of caffeine: an experimental study in rats

  title={Anxiogenic action of caffeine: an experimental study in rats},
  author={Salil Kumar Bhattacharya and Kalkunte S. Satyan and Amitabha Chakrabarti},
  journal={Journal of Psychopharmacology},
  pages={219 - 224}
The anxiogenic action of caffeine (10, 25 and 50 mg/kg, i.p.) was investigated in rats and compared with that of yohimbine (2 mg/kg, i.p.). The experimental methods used were the open-field, elevated plus-maze, social interaction and novelty-suppressed feeding latency tests. Caffeine produced a dose-related profile of behavioural changes, which were qualitatively similar to those induced by yohimbine and which indicate an anxiogenic activity in rodents. Thus, both the drugs reduced ambulation… 

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