Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain.

@article{Monzn2001AnxiogenesisIB,
  title={Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain.},
  author={Mar{\'i}a Elena Monz{\'o}n and Mariana Marcela Varas and Susana Rubiales de Barioglio},
  journal={Peptides},
  year={2001},
  volume={22 7},
  pages={1043-7}
}
In this study, the involvement of nitric oxide (NO) in the mechanism of anxiety was investigated. The rats received an intraamygdaline or intrahippocampal injection of the nitric oxide synthase inhibitor, N(G)-nitro-l-arginine (L-NOARG), and were then tested in the plus-maze test. L-NOARG induced a decrease in the time spent by rats in the open arms. Conversely, the administration of the melanin-concentrating hormone (MCH) into these structures increased the number of entries into the open arms… CONTINUE READING

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