Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease.

@article{Mah2015AnxietySI,
  title={Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease.},
  author={Linda Mah and Malcolm A. Binns and David C. Steffens},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year={2015},
  volume={23 5},
  pages={466-76}
}
OBJECTIVE To test the hypothesis that anxiety in amnestic mild cognitive impairment (aMCI) increases rates of conversion to Alzheimer disease (AD) and to identify potential neural mechanisms underlying such an association. METHODS Participants (N = 376) with aMCI from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were studied over a median period of 36 months. A Cox proportional-hazards model was used to assess the association between anxiety severity ratings on the Neuropsychiatric… CONTINUE READING
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