Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze.

@article{Miyasaka2002AnxietyrelatedBI,
  title={Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze.},
  author={Kyoko Miyasaka and Satoru Kobayashi and Minoru Ohta and Setsuko Kanai and Yuki Yoshida and Aki Nagata and Toshimitsu Matsui and Tetsuo Noda and Soichi Takiguchi and Yutaka Takata and Takako Kawanami and Akihiro Funakoshi},
  journal={Neuroscience letters},
  year={2002},
  volume={335 2},
  pages={115-8}
}
Cholecystokinin (CCK)-A receptor (AR) and B receptor (BR) share highly amino acid sequence homology and overlap in their tissue distribution. We examined the anxiety-related behavior of CCK-AR, CCK-BR, and CCK-ARBR gene knockout (-/-) mice in the elevated plus-maze. CCK-AR(-/-) mice showed a significantly higher frequency of open-arm entries than wild-type and CCK-BR(-/-) mice, whereas the percentage open-arm entry values in CCK-AR(-/-) mice did not differ from those in wild-type mice. Thus… CONTINUE READING