Anxiety caused by a short-life hypnotic

@article{Nicholson1982AnxietyCB,
  title={Anxiety caused by a short-life hypnotic},
  author={Anthony N. Nicholson and A. J. Belyavin and Barbara M. Stone and Mick B Spencer},
  journal={British Medical Journal (Clinical research ed.)},
  year={1982},
  volume={285},
  pages={215 - 215}
}
reports four deaths in 30 years attributed to milk-related infection as against a yearly toll of 150 000 deaths from coronary disease in England and Wales. The evidence which began to accumulate in the last 15 or so years about the possible connection between coronary disease and milk consumption comes from several independent studies: epidemiological, immunological, experimental, and clinical. Virtually every plant we eat-cereals, potatoes, carrots, onions, pulses, tomatoescontains substances… 
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  • 1984
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Ashton's careful study is the latest of several investigations that have shown quite unequivocally that benzodiazepines may produce pharmacological dependence in therapeutic dosage, and stems from the early symptoms of withdrawal being those of anxiety, so that when a patient becomes anxious after withdrawal of benzdiazepines this may be mistaken simply for a return of pre-existing anxiety.
Benzodiazepine Dependence
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  • 1986
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Clinicians in general tend to use long half‐life benzodiazepine hypnotics in patients who have difficulties maintaining sleep and short half-life Benzodiazepines for treating sleep onset insomnia.
Commentary 1
2. Pakes GE, Brogden RN, Heel RC et al. Triazolam: a review of its pharmacological properties and therapeutic efficacy in patients with insomnia. Drugs 1981 ;22:81-110. 3. Eberts FS, Philopoulos Y,
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The present overview aimed at analyzing the literature to illustrate withdrawal after decrease, discontinuation, or switch of psychotropic medications based on the drug class, finding that benzodiazepines should be substituted by medications that cause less dependence such as antidepressants and antipsychotics runs counter the available literature.
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Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.
Commentary 4
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