Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge

@article{Chen2019AntrodiaCA,
  title={Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge},
  author={Yu-Cheng Chen and Yi-Chang Liu and Mohamed El‐Shazly and Tung‐Ying Wu and Jan-Gowth Chang and Yang-Chang Wu},
  journal={International Journal of Molecular Sciences},
  year={2019},
  volume={20}
}
Reported cases of breast cancer have skyrocketed in the last decades with recent advances in examination techniques. Brest cancer has become the second leading cause of mortality among women worldwide, urging the scientific community to develop or find new drugs from natural sources with potent activity and a reasonable safety profile to tackle this ailment. Antrodia cinnamomea (AC) is a treasured medicinal fungus which has attracted attention due to its potent hepatoprotective and cytotoxic… 

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References

SHOWING 1-10 OF 64 REFERENCES
Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer.
  • K. Shang, T. Su, L. Shyur
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2017
Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis.
TLDR
It is demonstrated that AC exhibited antiproliferative and growth inhibition effects on HCT‑8 cells via induction of apoptosis and blocking of cell cycle progression, thus suggesting that it may have anticancer properties valuable for potential future therapeutic application for the treatment of CRC.
Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A
TLDR
Bioassay-guided fractionation of EEAC led to a major active compound, zhankuic acid A, as the bioactive marker, and these findings may represent an experimental basis for developing EEAC as a potential chemotherapeutic adjuvant.
The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells
TLDR
It is suggested that TCEE is a potential ingredient for developing an integrated chemotherapy for human liver cancer.
Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells
TLDR
The findings suggest that autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway may represent a new mechanism of anti-colorectal cancer action by A. cinnamomea.
Recent research and development of Antrodia cinnamomea.
Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway.
  • Y. Hsu, P. Kuo, Chun-ching Lin
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2007
...
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