Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification

@article{Mangold2008AntizymeAM,
  title={Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification},
  author={Ursula Mangold and Hiroyuki Hayakawa and Mark Coughlin and Karl M{\"u}nger and Bruce R. Zetter},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={604-613}
}
The potential tumor suppressor antizyme and its endogenous inhibitor (antizyme inhibitor, AZI) have been implicated in the ubiquitin-independent proteasomal degradation of proteins involved in cell proliferation as well as in the regulation of polyamine levels. We show here that both antizyme and AZI concentrate at centrosomes and that antizyme preferentially associates with the maternal centriole. Interestingly, alterations in the levels of these proteins have opposing effects on centrosomes… CONTINUE READING

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References

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Showing 1-10 of 33 references

Controlling centrosome number: licenses and blocks.

Current opinion in cell biology • 2006
View 1 Excerpt

Origins and consequences of centrosome aberrations in human cancers.

International journal of cancer • 2006
View 1 Excerpt

Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication

C Zou, J Li, +3 authors V Band
J Cell Biol • 2005
View 1 Excerpt

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