Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen

@article{Oehen1992AntivirallyPC,
  title={Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen},
  author={Stephan Oehen and Hanspeter Waldner and Thomas M. K{\"u}ndig and Hans Hengartner and Rolf Martin Zinkernagel},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={176},
  pages={1273 - 1281}
}
The basis of antiviral protection by memory cytotoxic T lymphocytes (CTL) was investigated in vivo and in vitro using lymphocytic choriomeningitis virus (LCMV) and recombinant vaccinia viruses expressing the LCMV-glycoprotein (vacc-GP) or -nucleoprotein (vacc-NP). The widely replicating LCMV with a tendency to persist induced solid long-term protective memory. The poorly replicating vaccinia recombinant viruses revealed in the vaccinated host that the antiviral capacity of the secondary immune… CONTINUE READING