Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen

@article{Oehen1992AntivirallyPC,
  title={Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen},
  author={S. Oehen and H. Waldner and T. K{\"u}ndig and H. Hengartner and R. Zinkernagel},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={176},
  pages={1273 - 1281}
}
  • S. Oehen, H. Waldner, +2 authors R. Zinkernagel
  • Published 1992
  • Biology, Medicine
  • The Journal of Experimental Medicine
  • The basis of antiviral protection by memory cytotoxic T lymphocytes (CTL) was investigated in vivo and in vitro using lymphocytic choriomeningitis virus (LCMV) and recombinant vaccinia viruses expressing the LCMV-glycoprotein (vacc-GP) or -nucleoprotein (vacc-NP). The widely replicating LCMV with a tendency to persist induced solid long-term protective memory. The poorly replicating vaccinia recombinant viruses revealed in the vaccinated host that the antiviral capacity of the secondary immune… CONTINUE READING
    Engineering generic vaccine vectors
    The kinetics of T cell responses

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