Antiviral therapy for chronic hepatitis C: past, present, and future

@article{Hayashi2005AntiviralTF,
  title={Antiviral therapy for chronic hepatitis C: past, present, and future},
  author={Norio Hayashi and Tetsuo Takehara},
  journal={Journal of Gastroenterology},
  year={2005},
  volume={41},
  pages={17-27}
}
Antiviral therapy for chronic hepatitis C has dramatically advanced since the discovery of the hepatitis C virus (HCV) in 1989 and the introduction of interferon (IFN) monotherapy in the early 1990s. The current standard therapy uses a combination of pegylated IFN and ribavirin. The duration of therapy and response to therapy are HCV genotype-specific. Genotype 1 patients require 48 weeks of the combination therapy for 50% successful viral elimination, while genotype 2 patients require 24 weeks… CONTINUE READING