Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA).

Abstract

It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are… (More)
DOI: 10.1016/j.coph.2016.08.015

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