Antiviral resistance and impact on viral replication capacity: evolution of viruses under antiviral pressure occurs in three phases.

@article{Nijhuis2009AntiviralRA,
  title={Antiviral resistance and impact on viral replication capacity: evolution of viruses under antiviral pressure occurs in three phases.},
  author={Monique Nijhuis and Noortje M. van Maarseveen and Charles A. B. Boucher},
  journal={Handbook of experimental pharmacology},
  year={2009},
  volume={189},
  pages={299-320}
}
Resistance development is a major obstacle to antiviral therapy, and all active antiviral agents have shown to select for resistance mutations. Aspects of antiviral resistance development are discussed for specific compounds or drug classes in the previous chapters, while this chapter provides an overview regarding the evolution of different viruses (HIV, HBV, HCV, and Influenza) under pressure of antiviral therapy. Virus replication is an error prone process resulting in a large number of… CONTINUE READING

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Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase

  • MC Huigen, PM van Ham, GL de, RM Kagan, CA Boucher, M Nijhuis
  • Retrovirology
  • 2008
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