Antiviral resistance and hepatitis B therapy.

  title={Antiviral resistance and hepatitis B therapy.},
  author={Marc G Ghany and Edward C Doo},
  volume={49 5 Suppl},
The management of chronic hepatitis B currently rests with long-term therapy using oral nucleoside analogs. The major limitation of long-term therapy is antiviral resistance. Antiviral resistance is due to the high rate of mutations that can occur during hepatitis B virus (HBV) replication and the selection of these mutants due to a replication advantage in the presence of the antiviral agent. Indeed, high rates of antiviral resistance have been found with long-term use of lamivudine, in up to… CONTINUE READING


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Entecavir at five years shows long-term maintenance of high genetic barrier to hepatitis B virus resistance

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