Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

@article{Saitoh2011AntiviralPV,
  title={Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.},
  author={T. Saitoh and T. Satoh and N. Yamamoto and S. Uematsu and O. Takeuchi and T. Kawai and S. Akira},
  journal={Immunity},
  year={2011},
  volume={34 3},
  pages={
          352-63
        }
}
  • T. Saitoh, T. Satoh, +4 authors S. Akira
  • Published 2011
  • Biology, Medicine
  • Immunity
  • Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce production of type I interferon (IFN) by plasmacytoid dendritic cells (pDCs) to protect the host from virus infection. We showed that the IFN-inducible antiviral protein Viperin promoted TLR7- and TLR9-mediated production of type I IFN by pDCs. Viperin expression was potently induced after TLR7 or TLR9 stimulation and Viperin localized to the cytoplasmic lipid-enriched compartments, lipid bodies, in pDCs. Viperin… CONTINUE READING
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