Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy.

@article{Clercq2006AntiviralP,
  title={Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy.},
  author={Erik de Clercq and Hugh J. Field},
  journal={British journal of pharmacology},
  year={2006},
  volume={147 1},
  pages={1-11}
}
Following the discovery of the first effective antiviral compound (idoxuridine) in 1959, nucleoside analogues, especially acyclovir (ACV) for the treatment of herpesvirus infections, have dominated antiviral therapy for several decades. However, ACV and similar acyclic nucleosides suffer from low aqueous solubility and low bioavailability following oral administration. Derivatives of acyclic nucleosides, typically esters, were developed to overcome this problem and valaciclovir, the valine… CONTINUE READING
64 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

Similar Papers

Loading similar papers…