Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai.

@article{Grienke2010AntiviralPA,
  title={Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai.},
  author={U. Grienke and M. Schmidtke and J. Kirchmair and K. Pfarr and P. Wutzler and R. D{\"u}rrwald and G. Wolber and K. Liedl and H. Stuppner and J. Rollinger},
  journal={Journal of medicinal chemistry},
  year={2010},
  volume={53 2},
  pages={
          778-86
        }
}
At present, neuraminidase (NA) inhibitors are the mainstay of pharmacological strategies to fight against global pandemic influenza. In the search for new antiviral drug leads from nature, the seed extract of Alpinia katsumadai has been phytochemically investigated. Among the six isolated constituents, four diarylheptanoids showed in vitro NA inhibitory activities in low micromolar ranges against human influenza virus A/PR/8/34 of subtype H1N1. The most promising constituent, katsumadain A (4… Expand
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