Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B.

@article{Fisicaro2010AntiviralIT,
  title={Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B.},
  author={Paola Fisicaro and Caterina Valdatta and Marco Massari and Elisabetta Loggi and Elisabetta Biasini and Luca Sacchelli and Maria Cristina Cavallo and Enrico Maria Silini and Pietro Andreone and Gabriele Missale and Carlo Ferrari},
  journal={Gastroenterology},
  year={2010},
  volume={138 2},
  pages={682-93, 693.e1-4}
}
BACKGROUND & AIMS The antiviral function of peripheral hepatitis B virus (HBV)-specific T cells can be increased in patients with chronic hepatitis B by blocking the interaction of programmed death (PD)-1 with its ligand PD-L1. However, no information is available about the effects of this blockade on intrahepatic lymphocytes. We studied T-cell exhaustion and the effects of PD-1/PD-L1 blockade on intrahepatic and circulating HBV-specific T cells in patients with chronic hepatitis B. METHODS A… CONTINUE READING
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