Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3.

@article{Burke2011AntiviralEO,
  title={Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3.},
  author={J Daniel Burke and Nahum Sonenberg and Leonidas C. Platanias and Eleanor N Fish},
  journal={Antiviral therapy},
  year={2011},
  volume={16 4},
  pages={577-84}
}
BACKGROUND Viral myocarditis is most frequently associated with infection by Coxsackievirus B3 (CVB3). Interferon (IFN)-β therapy has been studied and could reduce virally induced tissue damage and improve heart function. METHODS In the present study we have investigated the role of translational suppression in the context of an IFN-α/β-mediated antiviral immune response to CVB3 infection. Specifically, we examined the effects of IFN-α/β treatment of CVB3-infected mouse embryonic fibroblast… CONTINUE READING

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