Antiviral effects of a transgenic RNA-dependent RNA polymerase.

  title={Antiviral effects of a transgenic RNA-dependent RNA polymerase.},
  author={Jason G. Kerkvliet and Louisa M. Papke and Moses Rodriguez},
  journal={Journal of virology},
  volume={85 1},
Transgenic expression of the RNA-dependent RNA polymerase 3D(pol) inhibited infection of Theiler's murine encephalitis virus (TMEV), a picornavirus from which it was derived. Here, we infected 3D(pol) transgenic mice with another picornavirus, as well as an alphaherpesvirus and a rhabdovirus. 3D(pol) transgenic FVB mice had significantly lower viral loads and survived longer after infection with all three types of viruses than nontransgenic FVB mice. Viral inhibition among three different types… CONTINUE READING
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