Antiviral effect of strictinin on influenza virus replication.

  title={Antiviral effect of strictinin on influenza virus replication.},
  author={Repon Kumer Saha and Tadanobu Takahashi and Yuuki Kurebayashi and Keijo Fukushima and Akira Minami and Noriaki Kinbara and Masaki Ichitani and Yuko M. Sagesaka and Takashi Suzuki},
  journal={Antiviral research},
  volume={88 1},
Strictinin, which is a member of the ellagitanin family of hydrolyzable tannins, prevented replication of human, duck and swine influenza A viruses (IAVs) in vitro at non-toxic concentrations. The addition of strictinin at the same time as IAV inoculation to MDCK cells inhibited viral replication in a dose-dependent manner. Strictinin showed 50% inhibitory concentrations for IAVs from 0.09±0.021 to 0.28±0.037μM (mean±S.E.M.) by the focus-forming assay. Treatment of MDCK cells with strictinin… CONTINUE READING