Antiviral effect of brassinosteroids against herpes virus and arenaviruses.

@article{Wachsman2000AntiviralEO,
  title={Antiviral effect of brassinosteroids against herpes virus and arenaviruses.},
  author={M{\'o}nica B. Wachsman and Ester Mar{\'i}a L{\'o}pez and Javier A. Ram{\'i}rez and Lydia Raquel Galagovsky and Celia E. Coto},
  journal={Antiviral chemistry & chemotherapy},
  year={2000},
  volume={11 1},
  pages={
          71-7
        }
}
A natural brassinosteroid and a series of synthetic derivatives were found to be good inhibitors of herpes simplex virus type 1 (HSV-1) and arenavirus replication in cell culture. The synthetic compounds tested were analogues of the 24(S) ethylbrassinone. Compounds (22 R,23 R,24S)-2alpha, 3alpha,5alpha,22,23-pentahydroxy-stigmastan-6-one and (22R,23R,24S)-3beta-bromo-5alpha,22,23-trihydroxy stigmastan-6-one were cytotoxic at concentrations of 20-40 microM. (22S,23S,24S)-2alpha,3alpha,22,23… CONTINUE READING

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