Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation.

@article{Levine1996AntiviralEA,
  title={Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation.},
  author={Bruce L Levine and Joseph D Mosca and James L Riley and Richard G Carroll and Maryanne T. Vahey and Linda L. Jagodzinski and Kenneth Wagner and Douglas L. Mayers and Donald S. Burke and O S Weislow and D C St Louis and Carl H June},
  journal={Science},
  year={1996},
  volume={272 5270},
  pages={1939-43}
}
Because stimulation of CD4+ lymphocytes leads to activation of human immunodeficiency virus-type 1 (HIV-1) replication, viral spread, and cell death, adoptive CD4+ T cell therapy has not been possible. When antigen and CD28 receptors on cultured T cells were stimulated by monoclonal antibodies (mAbs) to CD3 and CD28 that had been immobilized, there was an increase in the number of polyclonal CD4+ T cells from HIV-infected donors. Activated cells predominantly secreted cytokines associated with… CONTINUE READING

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