Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals.

@article{Anderson2003AntiviralDA,
  title={Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals.},
  author={Peter L. Anderson and Thomas N Kakuda and Sagar Kawle and Courtney V Fletcher},
  journal={AIDS},
  year={2003},
  volume={17 15},
  pages={2159-68}
}
OBJECTIVES Nucleoside analog reverse transcriptase inhibitors (NRTI) are used in virtually all anti-HIV regimens. Clinical response depends on the intracellular formation of the pharmacologically active triphosphate moiety. Our objective was to quantify the pharmacological characteristics of zidovudine and lamivudine triphosphate in HIV-infected individuals. METHODS Peripheral blood mononuclear cells were obtained at multiple planned intervals from antiretroviral-naive adults participating in… CONTINUE READING
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