Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives.

@article{Tonelli2009AntiviralAC,
  title={Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives.},
  author={Michele Tonelli and Iana Vazzana and Bruno Tasso and Vito Boido and Fabio Sparatore and Maurizio Fermeglia and Maria Silvia Paneni and Paola Posocco and Sabrina Pricl and Paolo la Colla and Cristina Ibba and Barbara Secci and Gabriella Collu and Roberta Loddo},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 13},
  pages={
          4425-40
        }
}
Twelve aminoarylazocompounds (A-C) and 46 aryltriazene 7 derivatives (D-G) have been synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. Eight aminoazocompounds and 27 aryltriazene derivatives exhibited antiviral activity, sometimes of high level, against one or more viruses. A marked activity against BVDV and YFV was prevailing among the former compounds, while the latter type of compounds affected mainly CVB-2 and… CONTINUE READING
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