Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

@article{Kanerva2013AntiviralAA,
  title={Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus},
  author={A. Kanerva and P. Nokisalmi and I. Diaconu and A. Koski and V. Cerullo and Ilkka Liikanen and S. T{\"a}htinen and M. Oksanen and Raita Heiskanen and S. Pesonen and T. Joensuu and T. Alanko and K. Partanen and L. Laasonen and K. Kairemo and L. Kangasniemi and Akseli Hemminki},
  journal={Clinical Cancer Research},
  year={2013},
  volume={19},
  pages={2734 - 2744}
}
  • A. Kanerva, P. Nokisalmi, +15 authors Akseli Hemminki
  • Published 2013
  • Medicine
  • Clinical Cancer Research
  • Purpose: Multiple injections of oncolytic adenovirus could enhance immunologic response. In the first part of this article, the focus was on immunologic aspects. Sixty patients previously naïve to oncolytic virus and who had white blood cells available were treated. Thirty-nine of 60 were assessed after a single virus administration, whereas 21 of 60 received a “serial treatment” consisting of three injections within 10 weeks. In the second part, we focused on 115 patients treated with a… CONTINUE READING
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