Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

  title={Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus},
  author={A. Kanerva and P. Nokisalmi and I. Diaconu and A. Koski and V. Cerullo and Ilkka Liikanen and S. T{\"a}htinen and M. Oksanen and Raita Heiskanen and S. Pesonen and T. Joensuu and T. Alanko and K. Partanen and L. Laasonen and K. Kairemo and L. Kangasniemi and Akseli Hemminki},
  journal={Clinical Cancer Research},
  pages={2734 - 2744}
  • A. Kanerva, P. Nokisalmi, +15 authors Akseli Hemminki
  • Published 2013
  • Medicine
  • Clinical Cancer Research
  • Purpose: Multiple injections of oncolytic adenovirus could enhance immunologic response. In the first part of this article, the focus was on immunologic aspects. Sixty patients previously naïve to oncolytic virus and who had white blood cells available were treated. Thirty-nine of 60 were assessed after a single virus administration, whereas 21 of 60 received a “serial treatment” consisting of three injections within 10 weeks. In the second part, we focused on 115 patients treated with a… CONTINUE READING
    122 Citations
    The role of GM-CSF in enhancing immunotherapy of cancer.
    • 12
    Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma.
    • 24
    • PDF
    Corrigendum to "T-cell Subsets in Peripheral Blood and Tumors of Patients Treated With Oncolytic Adenoviruses".
    • PDF
    The Efficacy of Oncolytic Adenovirus Is Mediated by T-cell Responses against Virus and Tumor in Syrian Hamster Model
    • 45
    • PDF
    Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy.
    • 62
    • PDF
    Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy
    • 59
    • PDF


    Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF.
    • 207
    Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients.
    • 193
    • PDF
    Oncolytic viruses for induction of anti-tumor immunity.
    • 56
    Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus.
    • 125
    • PDF
    Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors
    • 103
    • PDF
    Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial.
    • 431
    • Highly Influential
    Oncolytic adenovirus based on serotype 3
    • 59
    • PDF
    Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer.
    • 52
    • PDF