Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus.

@article{Isorce2016AntiviralAO,
  title={Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus.},
  author={Nathalie Isorce and Barbara Testoni and Ma{\"e}lle Locatelli and Judith Fresquet and Michel Rivoire and Souphalone Luangsay and Fabien Zoulim and David Durantel},
  journal={Antiviral research},
  year={2016},
  volume={130},
  pages={36-45}
}
In HBV-infected patients, therapies with nucleoside analogues or IFNα remain ineffective in eradicating the infection. Our aim was to re-analyze the anti-HBV activity of a large panel of IFNs and cytokines in vitro using non-transformed cultured hepatocytes infected with HBV, to identify new immune-therapeutic options. HepaRG cells and primary human hepatocytes were infected with HBV and, when infection was established, treated with various concentrations of different IFNs or inflammatory… CONTINUE READING
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