Antiviral activity of topoisomerase II catalytic inhibitors against Epstein-Barr virus.


Herpesviruses require several cellular proteins for their lytic DNA replication including topoisomerase II (Topo II). Thus, Topo II could be an effective drug target against herpesviral infection. In this study, we examined several Topo II catalytic inhibitors for their potentials in blocking EBV replication and becoming efficacious antiviral agents. Topo… (More)
DOI: 10.1016/j.antiviral.2014.05.003