Antiviral activity of sulfated polysaccharides against African swine fever virus.

@article{GarcaVillaln1991AntiviralAO,
  title={Antiviral activity of sulfated polysaccharides against African swine fever virus.},
  author={Dolores Garc{\'i}a-Villal{\'o}n and Carmen Gil-Fern{\'a}ndez},
  journal={Antiviral research},
  year={1991},
  volume={15 2},
  pages={
          139-48
        }
}

Anionic Compounds as Inhibitors of African Swine Fever Virus Replication in Vero Cells

Aurintricarboxylic acid suppressed ASFV cytopathic effects at 5μg ml−1 and emerged as the most efficacious inhibitor with a selectivity index (S.I.) of 400, but inhibition was also found when they were added after virus adsorption, indicating that other mechanism (or mechanisms) are involved in viral inhibition.

Antiviral activity of natural and semisynthetic polysaccharides on the early steps of rubella virus infection.

Results indicated that polysaccharides blocked a step in virus replication subsequent to virus attachment, such as internalization and/or uncoating, while saccharide units play a minor role in antiviral properties.

Inhibition of herpes simplex virus infection by negatively charged and neutral carbohydrate polymers.

The data obtained indicate that the antiviral activity of polysaccharides was not only related to their electric charge, but other characteristics of the molecules such as the polymeric backbone, the carbohydrate moieties and the degree of polymerization could play a role in influencing their antiviral properties.

Extracellular Polymeric Substances: Still Promising Antivirals

The use of polyanions and, specifically, the use of EPSs, in antiviral therapy should be reconsidered because these macromolecules are non-specific and therefore they might be used against different variants or even different viruses.

Antiviral activity of lambda-carrageenan against influenza viruses in mice and severe acute respiratory syndrome coronavirus 2 in vitro

Investigating the broad spectrum antiviral activity of a naturally existing sulfated polysaccharide, lambda-carrageenan (λ-CGN), purified from marine red algae revealed that it efficiently inhibited both influenza A and B viruses, as well as currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and could be a promising antiviral agent for preventing infection by several respiratory viruses.

Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2

Investigating the broad spectrum antiviral activity of a naturally existing sulfated polysaccharide, lambda-carrageenan (λ-CGN), purified from marine red algae revealed that its intranasal administration to mice during influenza A viral challenge not only alleviated infection-mediated reductions in body weight but also protected 60% of mice from virus-induced mortality.

Polyvalent 2D Entry Inhibitors for Pseudorabies and African Swine Fever Virus.

The synthesis and biological evaluation of novel extracellular matrix-inspired entry inhibitors based on polyglycerol sulfate-functionalized graphene sheets show strong inhibitory effects, which are equal or better than the common standards enrofloxacin and heparin as demonstrated for ASFV and PrV.

Effects of Chrysanthemum indicum polysaccharide and its phosphate on anti-duck hepatitis a virus and alleviating hepatic injury.

  • K. MingYun Chen Yi Wu
  • Biology, Medicine
    International journal of biological macromolecules
  • 2017

References

SHOWING 1-10 OF 23 REFERENCES

Polysaccharides as Antiviral Agents: Antiviral Activity of Carrageenan

The results suggest that this sulfated polysaccharide inhibits a step in virus replication subsequent to viral internalization but prior to the onset of late viral protein synthesis.

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

Dextran sulfate and heparin were highly effective against HIV-1 replication even when present only during the 2-hr virus adsorption period and were not inhibitory to HIV- 1 reverse transcriptase unless they were used at concentrations in excess of those that inhibited HIV-2 replication.

Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus

Several sulfated polysaccharides proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus.

Effect of disodium phosphonoacetate and iododeoxyuridine on the multiplication of African swine fever virus in vitro.

Inhibition of ASFV replication by PAA suggests that this virus, like other herpesviruses, involves a virus-specific DNA polymerase in its replication mechanism.

New agents active against African swine fever virus

Megalomycin C was the most active of the four agents with respect to the concentration of compound that blocked the formation of infectious virus by 50%.

Effect of chloroquine on African swine fever virus infection.

The results support the hypothesis that ASFV enters the cells by adsorptive endocytosis and not by fusion with the plasma membrane.

Inhibition by Rifampin of African Swine Fever Virus Replication in Tissue Culture

Rifampin clearly inhibited the multiplication and cytopathogenicity of the virus in PK-15 cells, and the inhibition of virus replication was not due to the cell-granulating effect of rifampsin since cultures which were transiently pretreated for long as 90 hr with 200 mug of drug/ml supported viral replication to the same degree as untreated cultures.

Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.

Dextran sulfate was found to block the binding of virions to various target T lymphocytes, inhibit syncytia formation, and exert a potent inhibitory effect against HIV-1 in vitro at concentrations that may be clinically attainable in human beings.

Initial interaction of herpes simplex virus with cells is binding to heparan sulfate

We have shown that cell surface heparan sulfate serves as the initial receptor for both serotypes of herpes simplex virus (HSV). We found that virions could bind to heparin, a related