Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.

Abstract

Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) and activate cellular innate immunity. We show that the human IFN-inducible oligoadenylate synthetases-like (OASL) protein has antiviral activity and mediates RIG-I… (More)
DOI: 10.1016/j.immuni.2014.05.007

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Cite this paper

@article{Zhu2014AntiviralAO, title={Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.}, author={Jianzhong Zhu and Yugen Zhang and Arundhati C Ghosh and Rolando A Cuevas and Adriana Forero and Jayeeta Dhar and Mikkel S\oes Ibsen and Jonathan Leo Schmid-Burgk and Tobias Schmidt and Madhavi K. Ganapathiraju and Takashi Fujita and Rune Hartmann and Sailen Barik and Veit Hornung and Carolyn B Coyne and Saumendra N Sarkar}, journal={Immunity}, year={2014}, volume={40 6}, pages={936-48} }