Antiviral activity of berberine and related compounds against human cytomegalovirus.

  title={Antiviral activity of berberine and related compounds against human cytomegalovirus.},
  author={Kyoko Hayashi and Kazuki Minoda and Yasuo Nagaoka and Toshimitsu Hayashi and Shinichi Uesato},
  journal={Bioorganic & medicinal chemistry letters},
  volume={17 6},
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC(50) 0.68 microM) of 1 was equivalent to that (IC(50) 0.91 microM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis. 

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