Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

@article{Gigante2017AntiviralAO,
  title={Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.},
  author={Alba Gigante and Asier G{\'o}mez-SanJuan and Leen Delang and Changqing Li and Osk{\'i}a Bueno and Ana-Mar{\'i}a Gamo and Eva Mar{\'i}a Priego and M J Camarasa and Dirk Jochmans and Pieter Leyssen and Etienne Decroly and Bruno Coutard and Gilles Qu{\'e}rat and Johan Neyts and Mar{\'i}a-Jes{\'u}s P{\'e}rez-P{\'e}rez},
  journal={Antiviral research},
  year={2017},
  volume={144},
  pages={
          216-222
        }
}
Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted to humans by Aedes mosquitoes. Since 2005, CHIKV has been spreading worldwide resulting in epidemics in Africa, the Indian Ocean islands, Asia and more recently in the Americas. CHIKV is thus considered as a global health concern. There is no specific vaccine or drug available for the treatment of this incapacitating viral infection. We previously identified 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as selective… CONTINUE READING
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