Antiviral activity of A771726, the active metabolite of leflunomide, against Junín virus

@article{Seplveda2018AntiviralAO,
  title={Antiviral activity of A771726, the active metabolite of leflunomide, against Jun{\'i}n virus},
  author={C. Sep{\'u}lveda and Cybele C. Garcia and E. Damonte},
  journal={Journal of Medical Virology},
  year={2018},
  volume={90},
  pages={819 - 827}
}
The aim of this study was to investigate the effect of A771726, the active metabolite of leflunomide, (CONICET‐UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad against the infection with Junín virus (JUNV), agent of Argentine hemorrhagic fever (AHF). The treatment with non‐cytotoxic concentrations of A771726 of Vero and A549 cells infected with JUNV inhibited virus replication in a dose‐dependent manner, as determined by virus yield reduction assay. The… Expand
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