Antiviral activities of nucleotide heterodimers against human immunodeficiency virus type 1 in vitro.

@article{Ijichi1996AntiviralAO,
  title={Antiviral activities of nucleotide heterodimers against human immunodeficiency virus type 1 in vitro.},
  author={K. Ijichi and Masatoshi Fujiwara and Kenji Mori and Manami Morozumi and Haruhiko Machida and Shibro Shigeta and Katsuhiko Konno and Toyokazu Yokota and Masanori Baba},
  journal={Antiviral research},
  year={1996},
  volume={31 1-2},
  pages={115-20}
}
Nucleotide heterodimers were synthesized and examined for their inhibitory effects on the replication of human immunodeficiency virus type 1 (HIV-1), including HIV-1 reverse transcriptase (RT) inhibitor-resistant mutants. 3'-Azido-3'-deoxythymidilyl-(5')-phospho-(5')-6-[(3', 5'-dimethylphenyl)thio]-5-ethyl-1-[(2-hydroxyethoxy)methyl]uracil (AZT-P-E-HEPU-dM) and 3'-azido-3'-deoxythymidilyl-(5')-phospho-(5')-2', 3'-dideoxyinosine (AZT-P-ddI) proved to be highly potent and selective inhibitors of… CONTINUE READING