Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Poultry, Vietnam, 2009–2011

@inproceedings{Nguyen2013AntiviralSO,
  title={Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Poultry, Vietnam, 2009–2011},
  author={Ha Thi Thuy Nguyen and Tung P Nguyen and Vasiliy P. Mishin and Katrina Sleeman and Amanda L. Balish and Joyce Jones and Adrian Traian Creanga and Henju Marjuki and Timothy M. Uyeki and Dang Hoang Nguyen and Diep H. Nguyen and Hoa Thi Do and Alexander I. Klimov and Charles T. Davis and Larisa V. Gubareva},
  booktitle={Emerging infectious diseases},
  year={2013}
}
We assessed drug susceptibilities of 125 avian influenza A(H5N1) viruses isolated from poultry in Vietnam during 2009-2011. Of 25 clade 1.1 viruses, all possessed a marker of resistance to M2 blockers amantadine and rimantadine; 24 were inhibited by neuraminidase inhibitors. One clade 1.1 virus contained the R430W neuraminidase gene and reduced inhibition by oseltamivir, zanamivir, and laninamivir 12-, 73-, and 29-fold, respectively. Three of 30 clade 2.3.4 viruses contained a I223T mutation… CONTINUE READING