Antiviral Properties, Metabolism, and Pharmacokinetics of a Novel Azolo-1,2,4-Triazine-Derived Inhibitor of Influenza A and B Virus Replication

@article{Karpenko2010AntiviralPM,
  title={Antiviral Properties, Metabolism, and Pharmacokinetics of a Novel Azolo-1,2,4-Triazine-Derived Inhibitor of Influenza A and B Virus Replication},
  author={Inna L Karpenko and Sergey Deev and Oleg I. Kiselev and V. N. Charushin and Vladimir L. Rusinov and Eugene N. Ulomsky and E. G. Deeva and Dmitry V. Yanvarev and Alexander V Ivanov and Olga A Smirnova and Sergey N Kochetkov and Oleg N. Chupakhin and Marina K Kukhanova},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2010},
  volume={54},
  pages={2017 - 2022}
}
ABSTRACT Influenza viruses of types A and B cause periodic pandemics in the human population. The antiviral drugs approved to combat influenza virus infections are currently limited. We have investigated an effective novel inhibitor of human influenza A and B viruses, triazavirine {2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7(4Í)-one} (TZV). TZV suppressed the replication of influenza virus in cell culture and in chicken chorioallantoic membranes, and it protected mice from… Expand

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