Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and Counteraction

@inproceedings{Tortorec2011AntiviralIO,
  title={Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and Counteraction},
  author={Anna Le Tortorec and Suzanne Willey and Stuart J. D. Neil},
  booktitle={Viruses},
  year={2011}
}
Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's… CONTINUE READING
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